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Grape Seed Extract (OPC), 400mg

21.06 

In stock

In stock

 

Why this Grape Seed Extract (OPC)?

We love this product and formulation because it is:

  • HIGH STRENGTH: 400 mg Grape Seed Extract in One Capsule
  • ULTRA OPC CONCENTRATION: >95% OPC (>380mg Oligomeric Proanthocyanidins per capsule)
  • NO ADDITIVES: capsules contain Grape Seed Extract and nothing else
  • MADE IN EU – capsules are manufactured in the Netherlands
  • VEGAN CAPSULES, VEGAN INGREDIENTS
  • Major Keywords: Gut & Urinary tract health, Pain, Inflammation, Bacteria

GRAPE SEED EXTRACT – PURE STRENGTH

Description

 WHY MCS FORMULAS

Our focus at MCS Formulas is to provide some of the World’s best food supplements in terms of effectiveness and purity, and deliver that as fast as possible to our customers. This is why we provide the following:

ULTRAFAST WORLDWIDE SHIPPING: we ship to nearly every country around the World, using the best carriers, such as FedEx, UPS and DHL Express

MANY OF OUR PRODUCTS ARE WORLD’S BEST IN THEIR CATEGORY: We very much care about what goes into our products as we do our best to provide the best with a focus on

– maximizing effectiveness

  • we are using some of the highest quality ingredients sources available
  • while adding large amounts of active ingredients in each capsule
  • supported by formulations to improve absorption

– maximizing purity

  • we are testing raw materials prior to manufacturing the capsules using some of the largest analysis laboratories such as Eurofins
  • we are testing the product after manufacturing using one of Europe’s largest food testing laboratory, Agrolab in Germany
  • minimizing and in most of the cases not using any additive – this makes the production slow and expensive but delivers clean products for the user

WE VALUE LIFE: See our We Donate program

Note: MCS Formulas founder is also the founder of a health-related Blog (click here to see here the Blog), which has been visited by millions of people and has been providing science-based information for many years prior to the establishment of MCS Formulas.

WE DO ALL THIS BECAUSE WE CARE

WHY GRAPE SEED EXTRACT (OPC)

The key reason Grape Seed Extract is used as a food supplement is its high content of Oligomeric Proanthocyanidins (OPC), powerful substances found in the bark of trees, fruit skins, seeds, and leaves. Natural sources of OPCs include grape seeds and skins, blueberries, cranberries, and coffee.

Proanthocyanidins are developed by plants as a defense against biotic and abiotic stressors, protecting them from pathogens and predators. Unlike many plant extracts, OPCs can easily pass the intestinal barrier, facilitating their absorption (1).

The potential benefits of Proanthocyanidins are extensively studied, covering cardiovascular health, inflammation, skin health, immunity, brain health, gastrointestinal health, metabolic syndrome, microbial infections, and oncology. These benefits are likely related to their impact on the microbiome, increasing diversity and improving the balance of gut microbes (2).

Indeed, studies indicate that OPCs interact with intestinal microflora, supporting healthy levels of beneficial bacteria such as Bifidobacterium spp. and Lactobacillus spp. (3).

While there are various areas where OPCs can help, in our view, those that stand out the most are:

Microbial Infections – Gut & Urinary tract health

  • Pathogen Adhesion: Proanthocyanidins may represent a good support to help the body maintain a healthy response to the adhesion of pathogens to the mucosal surfaces, such as the urinary tract epithelium;
  • Biofilm Formation: microbes regulate through biofilm formation for survival from host defense, which is often found difficult in its eradication with simple anti-microbial agents. Research indicates Proanthocyanidins may represent a good support for the human body when it comes to adherence, motility and biofilm formation of major microbial infections including Candida albicans (4, 5, 6);
  • Viruses: Proanthocyanidins maintain a healthy response to external agents (7).

Oncology

  • Unhealthy Stem Cells: Proanthocyanidins may help reverse EMT through Suppression of TGF- β Signaling Pathway (8);
  • Angiogenesis: Grape seed proanthocyanidins inhibit MMP-2 and MMP-9 secretion, VEGF and angiopoietin 1 signaling, to inhibit angiogenesis (9);
  • Hypoxia-Inducible Factors: Proanthocyanidins supress HIF-1α-dependent pathway (10).

Inflammation and Pain

  • Gut Microbiota: Proanthocyanidins may contribute to maintaining a healthy gut microbiota, which is essential for a well-functioning immune system;
  • Neuropathic Pain: Proanthocyanidins have been shown to help suppress matrix metalloproteinase-9/2 (11), inflammasomes in macrophages (12), and inhibiting the activity of pyramidal cells in the insular cortex (13);
  • C-Reactive Protein (CRP) (14);
  • NF-κB Signaling Pathway: Inactivating the NF-κB signaling, and downregulating pro-inflammatory cytokines and mediators such as TNF-α, IL-6, and COX-2 (15, 16, 17, 18).

In conclusion, Proanthocyanidins are expected to contribute to a distinct gut microbiota profile that promotes health and wellbeing.

*The statements in this section have not been evaluated by the FDA or EFSA.

References

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10215713/
  2. https://www.oncotarget.com/article/13450/text/
  3. https://pubmed.ncbi.nlm.nih.gov/35114875/
  4. https://pubmed.ncbi.nlm.nih.gov/29775211/
  5. https://pubmed.ncbi.nlm.nih.gov/12058985/
  6. https://pubmed.ncbi.nlm.nih.gov/22248145/
  7. https://www.mdpi.com/1999-4915/15/4/884
  8. https://pubmed.ncbi.nlm.nih.gov/34354794/
  9. https://www.sciencedirect.com/science/article/pii/S0753332219305359#bib0150
  10. https://pubmed.ncbi.nlm.nih.gov/25385044/
  11. https://pubmed.ncbi.nlm.nih.gov/29929563
  12. https://pubmed.ncbi.nlm.nih.gov/25345607/
  13. https://www.frontiersin.org/articles/10.3389/fnmol.2023.1174125/full
  14. https://pubmed.ncbi.nlm.nih.gov/32921322/
  15. https://www.spandidos-publications.com/10.3892/ijmm.2017.2997
  16. https://link.springer.com/article/10.1007/s12204-012-1312-y
  17. https://pubmed.ncbi.nlm.nih.gov/20143255/
  18. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766935/

 PRODUCT DETAILS AND USE

Supplement Facts

Capsules per Container: 60 Amount Per Capsule %DV
Grape Seed Extract [Vitis vinifera L.] Standardized to
at least 95% Oligomeric Proanthocyanidins (OPCs)
400 mg *
Providing min. OPCs 380 mg *
* Daily Value [DV] not established


Other Ingredients

Vegetarian Capsule [HYPROMELLOSE], and Nothing Else.

Not manufactured with yeast, wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a Quality facility that processes milk, whey, soy, egg, fish and nuts.

Suggested use

As a dietary supplement, take 1 capsule daily with plenty of water, with a meal, or as directed by a healthcare professional.

Storage

Store in a cool dry place.

Warnings

If you are pregnant, nursing, taking any medications, please consult your healthcare practitioner before taking any dietary supplements. Do not use if inner bottle seal is missing, torn or damaged in any way. This product is not intended to diagnose, treat, cure, or prevent any disease. Food supplements: should not be used as a substitute for a varied and healthy lifestyle. Keep out of reach from children. Do not exceed the daily intake recommended by your healthcare provider.

Additional information

Weight 0.052 kg

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