Our focus at MCS Formulas is to provide some of the World’s best food supplements in terms of effectiveness and purity, and deliver that as fast as possible to our customers. This is why we provide the following:

ULTRAFAST WORLDWIDE SHIPPING with FedEx and UPS: we ship to nearly every country around the World, using the best carrier, that is FedEx

MANY OF OUR PRODUCTS ARE WORLD’S BEST IN THEIR CATEGORY: We very much care about what goes into our products as we do our best to provide the best with a focus on

– maximizing effectiveness

• we are using some of the best ingredients sources available,
• while adding large amounts of active ingredients in each capsule,
• supported by formulations to improve absorption

– maximizing purity

• we are testing raw materials prior to manufacturing the capsules using some of the largest analysis laboratories such as Eurofins
• we are testing the product after manufacturing using one of Europe’s largest food testing laboratory, Agrolab in Germany
• minimizing and in most of the cases not using any additive – this makes the production slow and expensive but delivers clean products for the user

WE ARE A SOCIAL ENTERPRISE. See our We Donate 50% program

Note: MCS Formulas founder is also the founder of a health related Blog (click here to see here the Blog), visited by > 0.5 million visitors each year, offering FREE information for people in need for many years prior to MCS Formulas existence.

WE DO ALL THIS BECAUSE WE CARE

Introduction on Resveratrol

Resveratrol is a naturally occurring substance produced by plants in response to stress such as injury, ultraviolet exposure, and fungal attack. Resveratrol is produced by more than 70 species of plants in response to such stressful situations, as a mechanism of resistance to parasites (to inhibit the development of an infection in the plant) and other adverse conditions (1).

Currently, Resveratrol is in most cases extracted from Japanese knotweed Polygonum. Yet the process is dependent on the variable harvest, and typically has low extraction yield and results in a low-purity product. Production of Resveratrol by fermentation represents an alternative process circumventing these disadvantages.

Resveratrol is found in nature as cis-resveratrol and trans-resveratrol. Of the 2 isomers, research has been focused on the trans-resveratrol isomer because it is thought to be more stable and more biologically active (2).

Wines, particularly red wines, are a source of some levels of resveratrol and has been suggested by some to be partially responsible for the French paradox (3). While the connection between the two is not yet clear from a scientific point of view, Resveratrol has been present in traditional medicinal preparations, such as darakchasava or manakka, for more than 2000 years (4).

Due to its outstanding properties and potential to affect the health in humans, Reveratrol has been intensively investigated by the academic research groups during the past decades.

Nevertheless, in contrast to its potential, the application of Reveratrol in humans presents important challenges. More specifically, while oral administration of Resveratrol in humans indicated that a good amount of resveratrol is absorbed, possibly by transepithelial diffusion, the oral bioavailability is low (<1%) due to rapid and extensive metabolism in the intestine and liver (3).

MCS Formulas provides an outstanding formula to support Resveratrol absorption …

Our Resveratrol capsules include the more biologically active form of Resveratrol, i.e. Trans-Resveratrol.

However, we did not stop here. Instead, in order to maximize the absorption of Trans-Resveratrol, we have designed a formula to also address two major bio-availability related mechanisms.

One well known “tool” known to maximize bio-availability of natural compounds such as Trans-Resveratrol is Piperine (5). As a result, we have included 2 mg BioPerine© providing >95% Piperine in each capsule.

The other major approach known to maximize bio-availability of natural compounds are phospholipid-based formulations. These are available commercially known as liposomal formulations and they come as liquid emulsions or solid formulations promoting the formation of liposomal structures (bubble-like structures surrounded by a fat-based layer) that can encapsulate the active ingredients such as Trans-Resveratrol compounds. This phospholipid layer is similar to the cell walls in our body. As a result, liposomes are well received by the body and absorbed in higher quantities by the body, to reach the blood stream.

While liposomal formulations are a great way to deliver increased amount of supplements and drugs to the blood stream, when turning these into products, it leads to various disadvantages for the users. Liposomal products are liquid, heavy and difficult to carry. They have difficult taste. Making their taste better may come with various undesired additives. And typically they have short shelf life, even shorter after the bottle is open. Furthermore, liquid liposomal products need to stay stored at low temperature.

In contrast to the liquid liposomal supplements, liposomal promoting formulations as dry powder in capsules have no taste, they are easy to carry, and they can be stored at room temperature with a long shelf life. The quality is therefore even better since the product is more stable.

Furthermore, phospholipids can be negatively or positively charged leading to a lower absorption and time to circulate in the blood stream, compared to neutrally charged liposomes. In order to address this and further maximize the absorption, out Pro Liposomal formula includes LongLifeLiposomal™.

LongLifeLiposomal™ is a liposomal technology that includes a proprietary blend of Phospholipids and Chitosan to promote the formation of neutrally charged liposomes. Indeed, it is known that Chitosan naturally binds to charged phospholipids to form neutrally charged liposomes. This is how, LongLifeLiposomal™ pro liposomal blend, supports the formation of liposomes that can have a better biocompatibility (improved absorption and a longer circulating time in the blood stream) compared to formulas based on phospholipids alone.

References

1. Hepatic Glucuronidation of Resveratrol: Interspecies Comparison of Enzyme Kinetic Profiles in Human, Mouse, Rat, and Dog https://www.sciencedirect.com/science/article/abs/pii/S134743671530611X
2. Bioavailability and safety study of resveratrol 500 mg tablets in healthy male and female volunteers https://www.spandidos-publications.com/10.3892/etm.2015.2895?text=fulltext
3. Capillary electrophoretic determination of resveratrol in wines https://pubmed.ncbi.nlm.nih.gov/10552635/
4. Properties of Resveratrol: In Vitro and In Vivo Studies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans https://www.hindawi.com/journals/omcl/2015/837042/
5. Enhancing the bioavailability of resveratrol by combining it with piperine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295233/