At MCS Formulas, our mission is to offer some of the world’s best food supplements in terms of effectiveness and purity, with fast, reliable delivery. Here’s what we provide:

ULTRAFAST WORLDWIDE SHIPPING: We ship to nearly every country across the globe, partnering with trusted carriers like FedEx, UPS, and DHL Express to ensure quick and secure delivery.

SOME OF THE WORLD’S BEST SUPPLEMENTS IN THEIR CATEGORY: We very much care about what goes into our products, and we are committed to offering the highest-quality supplements, focusing on two key areas:

– Maximizing Effectiveness:

• We source the finest ingredients available.
• Our supplements are packed with generous amounts of active ingredients per capsule.
• We use advanced formulations to enhance absorption for optimal results.

– Maximizing Purity:

• We test all raw materials before production through top laboratories like Eurofins.
• Post-manufacturing, we ensure further quality testing through Agrolab, one of Europe’s largest food testing labs.
• We minimize, and often eliminate, additives, even though this makes production slower and more costly. The result is a cleaner, purer product for you.

WE VALUE LIFE: Discover our commitment to giving back through our We Donate program

MCS Formulas was founded by a Doctor of Science, who previously created a highly respected health blog. For many years before the creation of MCS Formulas, this platform provided free, valuable health information to millions, driven purely by a genuine commitment to helping people (Ref.).

Piperlongumine: The Science

Piperlongumine, or piplartine, is a natural alkaloid substance extracted from the fruit of rots of the long pepper plant (Piper longum Linn.). The plant grows in the wild tropical rain forests of India, Indonesia, Malaysia, Nepal, Philippines, and Sri Lanka, and it has been considered one of the main components in the Ayurvedic medicine with important potential.

During the recent years, Piperlongumine has gain important scientific attention including in the healthy-aging space such as that related to senolytics. As such, Piperlongumine has been studied in relation to e.g. the intracellular ROS generation, NF-κB, STAT3, and TXNRD1.

1. Oxidative Balance
   Piperlongumine has been extensively studied for its role in influencing reactive oxygen species (ROS) within cells. ROS are molecules that include free radicals, such as hydrogen peroxide and superoxide, which are produced during normal cellular metabolism. Managing them effectively is crucial for supporting overall cellular health. High levels of ROS can lead to oxidative stress, which can damage cellular components like DNA, proteins, and lipids. Piperlongumine may support the body’s natural antioxidant defenses to maintain a balance.
   
   • ROS increase in certain cells: Research shows that Piperlongumine can promote an increase in ROS levels in some cells. Elevated ROS levels can affect cellular processes, depending on the balance between ROS production and the cell’s ability to manage oxidative stress through its antioxidant systems.
     
   • Interaction with antioxidant pathways: Piperlongumine is known to interact with the cellular antioxidant defense system, particularly the glutathione (GSH) and glutathione-S-transferase (GST) pathways. These pathways play a role in neutralizing ROS in cells, and Piperlongumine’s effects on these pathways have been observed in laboratory studies.
     
     
2. Apoptosis and Cell Renewal
   Apoptosis is the process of programmed cell death, a crucial function in maintaining healthy tissues and eliminating damaged cells. Studies indicate that Piperlongumine can influence the pathways involved in apoptosis. As such, Piperlongumine may support the body’s natural cell renewal processes by encouraging the maintenance of healthy apoptosis pathways, so that cells function optimally.
   
   • Mitochondrial involvement: Piperlongumine has been shown to influence mitochondrial pathways related to apoptosis. Mitochondria, the energy-producing organelles in cells, play a role in regulating the release of certain proteins, such as cytochrome c, which are involved in the apoptotic process.
     
   • Caspase activation: The activation of enzymes known as caspases has been observed in cells exposed to Piperlongumine. These enzymes help break down cellular components in a controlled manner during apoptosis.
     
   • Bcl-2 family proteins: Research indicates that Piperlongumine can affect the balance between proteins in the Bcl-2 family, which regulate apoptosis. These proteins include both pro-apoptotic and anti-apoptotic members, and their regulation is a key factor in determining whether a cell undergoes programmed cell death.
     
     
3. Modulation of the NF-κB Pathway
   The NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) pathway is involved in regulating various cellular processes, including gene expression related to inflammation and cell survival. Piperlongumine has been found to potentially work on this pathway.
   
   • Inhibition of NF-κB activation: Studies suggest that Piperlongumine can prevent the activation of NF-κB by inhibiting the nuclear translocation of the NF-κB complex, which affects the expression of certain genes. This modulation of the NF-κB pathway has been observed in laboratory settings.
     
   • IκBα stabilization: Piperlongumine has also been shown to interact with IκBα, a protein that inhibits NF-κB. By preventing the degradation of IκBα, Piperlongumine maintains its ability to regulate the NF-κB pathway.
     
     
4. Effects on Heat Shock Proteins (HSPs)
   Heat shock proteins (HSPs) are molecular chaperones that assist in protein folding and protect cells under stress. This contributes to the body’s ability to handle cellular stress and maintain healthy cellular functions. Piperlongumine has been studied for its effects on HSP70 and HSP90, which are involved in cellular stress responses.
   
   • HSP70 and HSP90 downregulation: Piperlongumine has been observed to reduce the expression of HSP70 and HSP90. These proteins play a role in helping cells cope with stress, and their downregulation can affect cellular processes under conditions of stress.
     
   • Impact on protein homeostasis: By influencing the expression of HSPs, Piperlongumine can disrupt the balance of protein homeostasis (proteostasis) within cells, which can lead to a buildup of misfolded proteins and the activation of stress responses.
     
     
5. Effects on Angiogenesis
   Angiogenesis, the formation of new blood vessels, is a process that supports tissue growth by supplying oxygen and nutrients. Piperlongumine has been studied for its effects on molecular pathways involved in angiogenesis.
   
   • Inhibition of VEGF signaling: Piperlongumine has been shown to reduce the activity of vascular endothelial growth factor (VEGF), a key factor in promoting angiogenesis. This inhibition has been observed in experimental models, where Piperlongumine reduced the expression of VEGF and related signaling molecules.
     
   • Downregulation of pro-angiogenic factors: In addition to VEGF, Piperlongumine affects other pro-angiogenic factors, such as fibroblast growth factor (FGF) and platelet-derived growth factor (PDGF), which also play roles in the formation of new blood vessels
     
     

Piperlongumine is a compound of interest in scientific research due to its ability to interact with several intracellular pathways. Its effects on oxidative stress, apoptosis, and molecular signaling are being explored in laboratory settings. Piperlongumine’s influence on ROS levels, apoptosis-related proteins, and key cellular pathways such as NF-κB and HSPs make it a promising molecule for further investigation.

Piperlongumine has also received relevant scientific attention in the search for senolytic compounds. Senolytics are a class of compounds that selectively target and eliminate senescent cells—cells that have stopped dividing but remain in the body, often contributing to aging and various age-related conditions. These “zombie” cells can release inflammatory signals that affect nearby healthy cells, potentially accelerating aging and tissue dysfunction.

These research findings highlight the importance of Piperlongumine in understanding how natural compounds can affect cellular mechanisms, with ongoing studies aimed at uncovering additional details about its role in molecular biology.

MCS Formulas provides the best and only one dedicated Piperlongumine food supplement …

To maximize the chance for effective support, next to our Long Pepper whole plant extract, we have made the effort to offer you a Piperlongumine product delivering an amount of Piperlongumine much higher compared to the whole plant Long Pepper capsules. While the whole plant contains a few percent Piperlongumine, our capsules contain a long pepper root extract delivering >95% Piperlongumine.

…. formulated in an outstanding absorption promoting formula

However, we did not stop here. Instead, in order to maximize the absorption of Piperlongumine, we have designed a formula to also maximize its bio-availability.

A major approach known to maximize bio-availability of natural compounds is the phospholipid-based formulation. Such formulations are known as liposomal formulations and commercially, they come as liquid emulsions or solid formulations promoting the formation of liposomal structures (bubble-like structures surrounded by a fat-based layer) that can encapsulate the active ingredients such as Piperlongumine. This phospholipid layer is similar to the cell walls in our body. As a result, liposomes are well received by the body and absorbed in higher quantities by the body, to reach the blood stream.

While liposomal formulations are a great way to deliver increased amount of supplements and drugs to the blood stream, when turning these into products, it leads to various disadvantages for the users. Liposomal products are liquid, heavy and difficult to carry. They have difficult taste. Making their taste better may come with various undesired additives. And typically they have short shelf life, even shorter after the bottle is open. Furthermore, liquid liposomal products need to stay stored at low temperature.

In contrast to the liquid liposomal supplements, liposomal promoting formulations as dry powder in capsules have no taste, they are easy to carry, and they can be stored at room temperature with a long shelf life. The quality is therefore even better since the product is more stable.

Furthermore, phospholipids can be negatively or positively charged leading to a lower absorption and time to circulate in the blood stream, compared to neutrally charged liposomes. In order to address this and further maximize the absorption, our Pro Liposomal formula includes LongLifeLipoTech™

LongLifeLipoTech™ is a pro liposomal technology that includes a proprietary blend of Phospholipids and Chitosan designed with the intention to promote the formation of neutrally charged liposomes. Indeed, it is known that Chitosan naturally binds to charged phospholipids to form neutrally charged liposomes. This is how, LongLifeLipoTech™ pro liposomal blend, supports the formation of liposomes that can have a better biocompatibility (improved absorption and a longer circulating time in the blood stream) compared to formulas based on phospholipids alone.

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