Our focus at MCS Formulas is to provide some of the World’s best food supplements in terms of effectiveness and purity, and deliver that as fast as possible to our customers. This is why we provide the following:

ULTRAFAST WORLDWIDE SHIPPING with FedEx and UPS: we ship to nearly every country around the World, using the best carrier, that is FedEx

MANY OF OUR PRODUCTS ARE WORLD’S BEST IN THEIR CATEGORY: We very much care about what goes into our products as we do our best to provide the best with a focus on

– maximizing effectiveness

• we are using some of the best ingredients sources available,
• while adding large amounts of active ingredients in each capsule,
• supported by formulations to improve absorption

– maximizing purity

• we are testing raw materials prior to manufacturing the capsules using some of the largest analysis laboratories such as Eurofins
• we are testing the product after manufacturing using one of Europe’s largest food testing laboratory, Agrolab in Germany
• minimizing and in most of the cases not using any additive – this makes the production slow and expensive but delivers clean products for the user

WE EXIST TO CONTRIBUTE TO SOCIETY. See our We Donate program

Note: MCS Formulas founder is also the founder of a health related Blog (click here to visit the Blog), visited by > 0.5 million visitors each year, offering FREE information for people in need for many years prior to MCS Formulas existence.

WE DO ALL THIS BECAUSE WE CARE

Piperlongumine, or piplartine, is a natural alkaloid substance extracted from the fruit of rots of the long pepper plant (Piper longum Linn.). The plant grows in the wild tropical rain forests of India, Indonesia, Malaysia, Nepal, Philippines, and Sri Lanka, and it has been considered one of the main components in the Ayurvedic medicine with important potential to support the human body when dealing with various health challenges (1).

During the recent years, Piperlongumine has gain important scientific attention in many areas of health, with predominance in oncology (2) and longevity space (3).

Indeed, in oncology it has been researched in relation to its potential to selectively targets tumor cells by generating cellular ROS, and a good number of key enzymes have been identified as targets of piperlongumine, such as NF-κB, STAT3, and TXNRD1 (2).

In the longevity area, Piperlongumine stands out as it has been found to have relevant senolytic properties. It has been shown to induce apoptosis in senescent cells on its own and to be synergic with other substances (3).

The main mechanism that seems to stay at the basis of Piperlongumine’s relevance in oncology and longevity area, is related to its activity towards inhibiting intracellular mechanisms responsible for antioxidant productions. As such, cells that have a higher sensitivity to reactive oxygen species such as senescent cells may be affected by Piperlongumine (4).

MCS Formulas provides the best and only one dedicated Piperlongumine food supplement …

To maximize the chance for effective support, next to our Long Pepper whole plant extract, we have made the effort to offer you a Piperlongumine product delivering an amount of Piperlongumine much higher compared to the whole plant Long Pepper capsules. While the whole plant contains a few percent Piperlongumine, our capsules contain a long pepper root extract delivering >95% Piperlongumine.

…. formulated in an outstanding absorption promoting formula

However, we did not stop here. Instead, in order to maximize the absorption of Piperlongumine, we have designed a formula to also maximize its bio-availability.

A major approach known to maximize bio-availability of natural compounds is the phospholipid-based formulation. Such formulations are known as liposomal formulations and commercially, they come as liquid emulsions or solid formulations promoting the formation of liposomal structures (bubble-like structures surrounded by a fat-based layer) that can encapsulate the active ingredients such as Piperlongumine. This phospholipid layer is similar to the cell walls in our body. As a result, liposomes are well received by the body and absorbed in higher quantities by the body, to reach the blood stream.

While liposomal formulations are a great way to deliver increased amount of supplements and drugs to the blood stream, when turning these into products, it leads to various disadvantages for the users. Liposomal products are liquid, heavy and difficult to carry. They have difficult taste. Making their taste better may come with various undesired additives. And typically they have short shelf life, even shorter after the bottle is open. Furthermore, liquid liposomal products need to stay stored at low temperature.

In contrast to the liquid liposomal supplements, liposomal promoting formulations as dry powder in capsules have no taste, they are easy to carry, and they can be stored at room temperature with a long shelf life. The quality is therefore even better since the product is more stable.

Furthermore, phospholipids can be negatively or positively charged leading to a lower absorption and time to circulate in the blood stream, compared to neutrally charged liposomes. In order to address this and further maximize the absorption, our Pro Liposomal formula includes LongLifeLipoTech™

LongLifeLipoTech™ is a liposomal technology that includes a proprietary blend of Phospholipids and Chitosan to promote the formation of neutrally charged liposomes. Indeed, it is known that Chitosan naturally binds to charged phospholipids to form neutrally charged liposomes. This is how, LongLifeLipoTech™ pro liposomal blend, supports the formation of liposomes that can have a better biocompatibility (improved absorption and a longer circulating time in the blood stream) compared to formulas based on phospholipids alone.

References

1. The promising potential of Piperlongumine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400693/
2. https://pubmed.ncbi.nlm.nih.gov/30006159/ https://pubmed.ncbi.nlm.nih.gov/25175943/
3. Discovery of piperlongumine as a potential novel lead for the development of senolytic agents https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191878/
4. A guide to senolytic intervention in neurodegenerative disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627445/