In the realm of cutting-edge biotechnology and anti-aging research, Nicotinamide Mononucleotide, a form of vitamin B3 (nicotinic acid) often abbreviated as NMN, has emerged as a promising and captivating molecule. NMN is garnering significant attention for its potential to unlock the secrets of longevity and vitality. This small but powerful compound plays a pivotal role in the intricate world of cellular metabolism, offering a glimpse into the mechanisms that govern aging and age-related diseases.
NMN is a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme crucial for a wide range of cellular processes. It is literally an amide of nicotinic acid and therefore an alternative form of vitamin B3. As a precursor of NAD+, it means that after taking NMN, our cells will convert it into NAD+. NMN is found in small amounts in various foods, such as avocados, broccoli, cabbage, edamame, and cucumbers.
As we age, our NAD+ levels decline, which is believed to contribute to various age-related ailments, including reduced energy production, DNA damage, and impaired cellular repair mechanisms. NMN supplementation, through its role in boosting NAD+ levels, has thus captured the imagination of scientists, researchers, and health enthusiasts alike (1, 2, 3).
In oncology, it has been suggested that high dose NMN promotes ferroptosis through NAM-mediated SIRT1-AMPK-ACC signaling (4). Other studies have suggested positive effects of NMN on cancer cells (5). However, the effect of NAD+ supplementation in oncology is strongly debated, and therefore, it is recommended that oncology patients discuss with their healthcare professional prior to using an NMN supplement.
NMN has been available as a food supplement for a relatively long time, in various countries around the world. However, more recently there is a debate if NMN can be sold as a food supplement. For example, in Europe, NMN with purity between 95% and 99% is listed on the novel food list. This is somewhat misleading for many, assuming and claiming it is illegal to sell NMN in Europe. This is however not the case. Our communication with EU relevant organizations, have clarified that the novel food listing of NMN refers to NMN products containing equal or l>95% NMN, while that does not apply on concentrations <95%.
MCS Formulas, has formulated its NMN Restore product such that it complies with the EU regulations (i.e. the content of phospholipids and chitosan lead to a content of NMN <95% per capsule), while we did our best to offer an effective dose of NMN in a capsule (i.g. 250 mg) and the maximum support via our LongLifeLipoTech™ technology platform.
NMN Restore, formulated in an outstanding absorption promoting formula
In order to further maximize the absorption of NMN, we have included NMN in our pro liposomal technology platform.
A major approach known to maximize bio-availability of natural compounds is the phospholipid-based formulation. Such formulations are known as liposomal formulations and commercially, they come as liquid emulsions or solid formulations promoting the formation of liposomal structures (bubble-like structures surrounded by a fat-based layer) that can encapsulate the active ingredients such as NMN. This phospholipid layer is similar to the cell walls in our body. As a result, liposomes are well received by the body and absorbed in higher quantities by the body, to reach the blood stream.
While liposomal formulations are a great way to deliver increased amount of supplements and drugs to the blood stream, when turning these into products, it leads to various disadvantages for the users. Liposomal products are liquid, heavy and difficult to carry. They have difficult taste. Making their taste better may come with various undesired additives. And typically they have short shelf life, even shorter after the bottle is open. Furthermore, liquid liposomal products need to stay stored at low temperature.
In contrast to the liquid liposomal supplements, liposomal promoting formulations as dry powder in capsules have no taste, they are easy to carry, and they can be stored at room temperature with a long shelf life. The quality is therefore even better since the product is more stable.
Furthermore, phospholipids can be negatively or positively charged leading to a lower absorption and time to circulate in the blood stream, compared to neutrally charged liposomes. In order to address this and further maximize the absorption, our Pro Liposomal formula includes LongLifeLipoTech™
LongLifeLipoTech™ is a liposomal technology that includes a proprietary blend of Phospholipids and Chitosan to promote the formation of neutrally charged liposomes. Indeed, it is known that Chitosan naturally binds to charged phospholipids to form neutrally charged liposomes. This is how, LongLifeLipoTech™ pro liposomal blend, supports the formation of liposomes that can have a better biocompatibility (improved absorption and a longer circulating time in the blood stream) compared to formulas based on phospholipids alone.