Why Magnesium Glycinate (also called Magnesium Bisglycinate) by MCS Formulas?
When it comes to magnesium supplementation, Magnesium Glycinate stands out as one of the most bioavailable and well-tolerated forms. In this form, magnesium is chelated — meaning it is bound to two molecules of the amino acid glycine. This chelation helps magnesium pass easily through the intestinal wall, leading to superior absorption and higher bioavailability compared to other forms.
Better absorption means more usable magnesium for your body to support vital functions such as muscle and nerve health, energy production, and relaxation — all without the digestive discomfort common with other forms.
The truth about elemental magnesium content
Pure Magnesium Glycinate naturally contains about 14% elemental magnesium. Some manufacturers try to market higher elemental magnesium content by blending in cheaper, poorly absorbed forms like magnesium oxide. While this makes the label look impressive, it does not mean better effectiveness — in fact, it usually leads to lower absorption and more digestive issues.
For this reason, it’s important to check the full ingredient list, not just the front label. Watch for added magnesium oxide or “buffered” bisglycinate blends that may contain hidden forms of magnesium.
Tip to identify hidden magnesium oxide: An easy way to spot if a product contains added magnesium oxide is to check the capsule weight versus the listed elemental magnesium content. For example, if a capsule weighs 500 mg (which is typical), there should be no more than about 70 mg (i.e. 14%) of elemental magnesium per capsule. If the label shows significantly more, it’s likely that cheaper forms such as magnesium oxide have been added.
At MCS Formulas, we believe in transparency and effectiveness over marketing gimmicks. We use pure Magnesium Glycinate, with no added magnesium oxide, ensuring you get only the most gentle, highly bioavailable, and effective magnesium your body deserves.
Comparing magnesium forms
Below is an overview of the most common magnesium forms, highlighting (qualitatively) our view on their absorption, digestive tolerance, and cost-effectiveness per mg of elemental magnesium.
Key insights
Absorption & Tolerance
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Magnesium Glycinate is highly absorbed and particularly gentle on the stomach, making it ideal for daily use without laxative side effects.
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Magnesium Citrate is also well absorbed but often causes a laxative effect, which may not be suitable for everyone.
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L-Threonate has moderate absorption and is praised for its potential cognitive benefits.
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Oxide, Sulfate, and Carbonate forms have low absorption and can cause significant gastrointestinal discomfort.
Affordability
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Oxide, Chloride, Sulfate, Carbonate: These forms are cheaper but less effective. They are often used to make products appear higher in magnesium content on the label.
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Glycinate, L-Threonate, Taurate, Orotate: These are more expensive but chosen for their superior bioavailability and health benefits.
Organic vs. Inorganic Magnesium Forms
A helpful way to understand magnesium supplements is to look at organic vs. inorganic forms:
Organic magnesium
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Bound to carbon-containing compounds (e.g., amino acids or organic acids).
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Generally better absorbed, with bioavailability between 20–35%.
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Examples: Glycinate, Citrate, Malate, Orotate.
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Gentler on the digestive system.
Inorganic magnesium
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Bound to mineral salts without a carbon backbone.
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Lower absorption, around 4–20% bioavailability.
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Examples: Oxide, Chloride, Sulfate, Carbonate.
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More likely to cause digestive upset and laxative effects.
When choosing a magnesium supplement, focusing on actual absorption and tolerability is far more important than simply looking at the label’s elemental magnesium content. Magnesium Glycinate offers a powerful combination of high absorption, a gentle digestive profile, and reliable effectiveness — making it one of the best choices for overall magnesium support.
References:
- Magnesium Glycinate https://pubchem.ncbi.nlm.nih.gov/compound/Magnesium-Glycinate
- Magnesium: Biochemistry, Nutrition, Detection, and Social Impact https://pmc.ncbi.nlm.nih.gov/articles/PMC8065437/
- The Importance of Magnesium in Clinical Healthcare https://pmc.ncbi.nlm.nih.gov/articles/PMC5637834/
*The statements in this section have not been evaluated by the FDA or EFSA.
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