Glycolysis Inhibithree is a blend of three naturally occurring compounds derived from traditional botanical sources: Phlorizin, Tanshinone IIA, and Shikonin. These compounds are sourced from the bark of apple trees, the roots of Salvia miltiorrhiza (Danshen), and Lithospermum erythrorhizon, respectively. Historically used in traditional practices, these ingredients have been the subject of scientific studies focused on their molecular properties and interactions with cellular systems.
Phlorizin – 100 mg Phlorizin
Phlorizin is a polyphenolic compound found primarily in the bark of apple trees (Malus domestica). It has been a point of interest in botanical research due to its potential molecular interactions. Scientific studies have explored its interactions with glucose transport systems in various biological contexts, particularly its association with sodium-glucose co-transporters (SGLT1 and SGLT2) (Ref.). These transporters are involved in glucose movement across cell membranes, and research continues to investigate how compounds like Phlorizin interact with these biological systems.
Scientific research on Phlorizin primarily focuses on its intracellular mechanism centered on SGLT1 and SGLT2. (Ref.)
Tanshinone IIA – 10 mg Tanshinone IIA
Tanshinone IIA is extracted from the root of Salvia miltiorrhiza (Danshen), a traditional herb that has been studied for its chemical composition. Among its properties, Tanshinone IIA has been investigated for its connection with HK2 (Hexokinase II) and Lactate Dehydrogenase (LDH) (Ref.), an enzyme involved in metabolic processes such as the conversion of pyruvate to lactate. This connection is of interest to researchers studying energy production and cellular metabolism.
Scientific research on Tanshinone IIA primarily focuses on its intracellular mechanism centered on HK2 (Hexokinase II), LDH; NF-κB Pathway and TNF-α, IL-6, and IL-1β; STAT3; mTOR Pathway, nitric oxide (NO), VEGF/VEGFR2; Ferroptosis (Ref.).
Shikonin – 8 mg Shikonin
Shikonin is a naturally occurring compound derived from the roots of Lithospermum erythrorhizon (Zi Cao). It has been traditionally used in various applications and has attracted attention in modern research due to its unique chemical structure. Studies have explored Shikonin’s association with Pyruvate Kinase M2 (PKM2), a key enzyme involved in glycolytic pathways (Ref.). This research is ongoing, particularly in understanding how compounds like Shikonin interact with metabolic enzymes.
Scientific research on Shikonin primarily focuses on its intracellular mechanism centered on Pyruvate Kinase M2 (PKM2) as well as NF-κB, PI3K/Akt/MAPKs, Akt/mTOR, TGF-β, GSK3β, TLR4/Akt.
As such, Glycolysis Inhibithree is a unique food supplement designed with the GLYCOLYSIS (Fermentation) pathway in mind. Each of the ingredients in Glycolysis Inhibithree is sourced from natural plant-based materials with a long history of traditional use. Modern scientific studies have focused on their molecular interactions with enzymes and transporters within biological systems, especially related to sodium-glucose co-transporters, HK2 (Hexokinase II) and Pyruvate Kinase M2 (PKM2). While Glycolysis Inhibithree does not make any claims about health benefits, the ingredients have been extensively researched in the context of their interactions with cellular and biochemical processes.
*The statements in this section have not been evaluated by the FDA or EFSA.
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