Our focus at MCS Formulas is to provide some of the World’s best food supplements in terms of effectiveness and purity, and deliver that as fast as possible to our customers. This is why we provide the following:

ULTRAFAST WORLDWIDE SHIPPING: we ship to nearly every country around the World, using the best carriers, such as FedEx and UPS

MANY OF OUR PRODUCTS ARE WORLD’S BEST IN THEIR CATEGORY: We very much care about what goes into our products as we do our best to provide the best with a focus on

– maximizing effectiveness

• we are using some of the best ingredients sources available,
• while adding large amounts of active ingredients in each capsule,
• supported by formulations to improve absorption

– maximizing purity

• we are testing raw materials prior to manufacturing the capsules using some of the largest analysis laboratories such as Eurofins
• we are testing the product after manufacturing using one of Europe’s largest food testing laboratory, Agrolab in Germany
• minimizing and in most of the cases not using any additive – this makes the production slow and expensive but delivers clean products for the user

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Note: MCS Formulas founder is also the founder of a health related Blog (click here to visit the Blog), visited by > 0.5 million visitors each year, offering FREE information for people in need for many years prior to MCS Formulas existence.

WE DO ALL THIS BECAUSE WE CARE

Fisetin is a plant extract, and an important phytoflavonoid frequently present in vegetables (onions and cucumbers), fruits (mangoes, apples, strawberries, kiwis and grapes), wine, and nuts. Fisetin concentrations in these fruits and vegetables are varied leading to an average daily intake estimate of 0.4 mg. The highest concentration of Fisetin was found in strawberries (160 ug/g) (1, 2).

During the past decade Fisetin has been intensively study especially in the field of oncology and anti-aging. In oncology, the most relevant mechanisms investigated were in relation to epithelial to mesenchymal transition, impact on CD44 and CD133 as well as hyaluronan synthesis and MMPs expression (3).

In the life extension and anti-aging field, Fisetin has been investigated in relation to its potential to support the body for a healthy level of self-destruction of the senescent cells.(4) Senescent cells are cells that they eventually stop multiplying but don’t die off when they should. They are spread across the body and have stopped contributing to essential functions, while having negative and aging effects on surrounding healthy cells. Although they no longer work properly, they are not eliminated from the body while the number of senescent cells increases and accumulates with age. These cells are responsible for aging and age-related health issues.(5)

Wile its potential to contribute to a healthy long life is fantastic, Fisetin is very hydrophobic in nature, resulting in limited water solubility, and thus a very limited bio-availability.

MCS Formulas provides the best Fisetin in one of the highest dose available …

To maximize the chance for effective support, our Fisetin capsules include one of the largest amount of Fisetin available in one capsule.

…. formulated in an outstanding absorption promoting formula

However, we did not stop here. Instead, in order to maximize the absorption of Fisetin, we have designed a formula to also maximize its bio-availability.

A major approach known to maximize bio-availability of natural compounds is the phospholipid-based formulation. Such formulations are known as liposomal formulations and commercially, they come as liquid emulsions or solid formulations promoting the formation of liposomal structures (bubble-like structures surrounded by a fat-based layer) that can encapsulate the active ingredients such as Fisetin. This phospholipid layer is similar to the cell walls in our body. As a result, liposomes are well received by the body and absorbed in higher quantities by the body, to reach the blood stream.

While liposomal formulations are a great way to deliver increased amount of supplements and drugs to the blood stream, when turning these into products, it leads to various disadvantages for the users. Liposomal products are liquid, heavy and difficult to carry. They have difficult taste. Making their taste better may come with various undesired additives. And typically they have short shelf life, even shorter after the bottle is open. Furthermore, liquid liposomal products need to stay stored at low temperature.

In contrast to the liquid liposomal supplements, liposomal promoting formulations as dry powder in capsules have no taste, they are easy to carry, and they can be stored at room temperature with a long shelf life. The quality is therefore even better since the product is more stable.

Furthermore, phospholipids can be negatively or positively charged leading to a lower absorption and time to circulate in the blood stream, compared to neutrally charged liposomes. In order to address this and further maximize the absorption, our Pro Liposomal formula includes LongLifeLipoTech™

LongLifeLipoTech™ is a liposomal technology that includes a proprietary blend of Phospholipids and Chitosan to promote the formation of neutrally charged liposomes. Indeed, it is known that Chitosan naturally binds to charged phospholipids to form neutrally charged liposomes. This is how, LongLifeLipoTech™ pro liposomal blend, supports the formation of liposomes that can have a better biocompatibility (improved absorption and a longer circulating time in the blood stream) compared to formulas based on phospholipids alone.

Science & Research

Do you want to learn more about the science behind Fisetin and the related cellular mechanisms? Please go to our Science & Research section that will be soon expanded to cover many important scientific findings.

References

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802565/
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689181/
3. https://pubmed.ncbi.nlm.nih.gov/30076913/
4. https://pubmed.ncbi.nlm.nih.gov/30279143/
5. https://www.nia.nih.gov/news/does-cellular-senescence-hold-secrets-healthier-aging