The origin of Shiitake (also called Lentinula edodes) seems to go back to over one hundred million years, and was first mentioned in traditional Chinese medicine texts 2000 years ago. It grows in regions such as Japan, China, Taiwan, Indonesia, and it is also the second most popular edible mushroom, after the button mushroom.
Shiitake includes molecules with potential positive effects on human health such as phenolic compounds and ergothioneine, ergosterol, β-glucans, eritadenine, peptides, lenthionine (1). Of these β-glucans are the most researched compounds to their outstanding potential for contribution to human health.
β-glucans are part of the polysaccharides group, and are major cell wall structural components in fungi, yeast, some bacteria, and cereal plants such as oats and barley. Some of the most well-known β-glucans are krestin and lentinan because they are licensed as drugs in Japan (2). Krestin (also known as PSK) is derived from Coriolus versicolor (Turkey Tail mushroom). Lentinan on the other hand is purified β-glucan from Shiitake mushrooms. Most of the research connects the activity of β-glucans with their impact on the immune system (3).
*The statements in this section have not been evaluated by the FDA or EFSA.
TIP: if you are searching for more food supplements containing β-glucans, please also see our Agaricus Extract capsules and Maitake Liquid Extract.
Science & Research
During the past decade extracts from Shiitake such as Lentinan have been intensively studied, including in clinical trials on humans:
Do you want to learn more about the science behind Shiitake and the related cellular mechanisms? Please go to our Health & Science section that will be soon expanded to cover many important scientific findings.
References
- β-D-glucans from Shiitake mushrooms https://pubmed.ncbi.nlm.nih.gov/31826486/
- Lentinan in Japan https://pubmed.ncbi.nlm.nih.gov/23092289/
- Lentinan https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664515/
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